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Distribution of ⁷⁵Se-Selenomethionine as Influenced by the Route of Administration

Veterans Administration Hospital, Hines, Illinois
Loyola University Stritch School of Medicine, and University of Illinois College of Medicine, Chicago, Illinois

Correspondence: For reprints contact: L. A. Graham, Veterans Administration Hospital, Hines, Ill. 60141.

ABSTRACT

Organ distribution data were obtained for rats following the administration of ⁷⁵Se-selenomethionine in trace quantities by the intravenous, oral, subcutaneous, and intraperitoneal routes. The tissue distribution and the concentration of isotope were similar except shortly after administration when the expected high concentrations are present at the site of administration.

The addition of carrier methionine had little effect on the concentration and distribution of ⁷⁵Se-selenomethionine. A reduction of more than 50% was observed in the plasma following the addition of carrier selenomethionine. Smaller decreases were also observed in the remaining tissues examined although the distribution patterns were similar.