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¹⁵⁷Dy-HEDTA for Skeletal Imaging

Upstate Medical Center, Syracuse, New York

M. W. Greene and E. Lebowitz

Brookhaven National Laboratory, Upton, New York

Correspondence: For reprints contact: Gopal Subramanian, Div. of Nuclear Medicine, Dept. of Radiology, Upstate Medical Center, 750 E. Adams St., Syracuse, N.Y. 13210.

ABSTRACT

Dysprosium-157 appears to be the best rare-earth nuclide available for skeletal imaging using either rectilinear scanner or scintillation camera. It is readily produced in a cyclotron from natural terbium, but the p,3n reaction requires protons of 33 MeV. Its monoenergetic gamma emission of 326 keV, with an external photon yield of 91%, is more suitable for use with the Anger camera than the higher energy photons of ¹⁸F or ³⁵Sr. Its half-life (8.1 hr) is 4.4 times greater than ¹⁸F, so that shipping problems are not as great. Imaging studies may be performed 4–6 hr, or 18–24 hr after administration. The skeletal localization of the HEDTA chelate is similar to other heavier lanthanons studied previously. Fortunately, there is no gastrointestinal excretion to obscure the abdominal or pelvic bones, as occurs with nuclides of strontium or barium. Fracture sites in experimental animals were well demonstrated by imaging, so that it is likely that other lesions including skeletal metastases will be detected also.