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Use of ¹³N in Studies of Airway Closure and Regional Ventilation

Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

Correspondence: For reprints contact: Reginald Greene, Massachusetts General Hospital, Boston, Massachusetts 02114.

ABSTRACT

The technique and potential clinical advantages of airway closure and pulmonary ventilation studies with high-specific-activity ¹³N-labeled molecular nitrogen are presented. External detection of ¹³N is described in ventilation studies, and the simultaneous monitoring of lung volume changes and of expired ¹³N boluses are described in airway closure measurements. The application of these studies may be of particular significance in the early detection of obstructive lung disease and pathophysiological mechanisms involving the lung in cardiorespiratory disorders.