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Ischemia of the Lung Due to Ionizing Radiation: Quantitative Studies

College of Physicians and Surgeons, Columbia University, New York, New York

Correspondence: For reprints contact: Philip M. Johnson, Div. of Nuclear Medicine, Presbyterian Hospital, 622 W. 168th St., New York, N.Y. 10032.

ABSTRACT

The effect of graded doses of ionizing radiation on pulmonary blood flow was measured quantitatively in the Swiss mouse. The experimental data indicate that pulmonary blood flow is reduced following radiation doses ranging from 100 to 4,000 R. The intensity of radiation-induced pulmonary ischemia is affected by the size of the radiation dose and the length of survival following treatment. There was no evidence of a limiting process nor of recovery from radiation-induced pulmonary ischemia during survival periods extending to half the life span of the experimental animal.