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Influence of Water and Mannitol Loads on Radio-Hippuran Renal Function Curves

University Hospital, Boston University Medical Center and Boston Veterans Administration Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Melvin H. Farmelant, St. Vincent Hospital, 25 Winthrop St., Worcester, Mass. 01610.

ABSTRACT

Urine flow rate was altered in normal subjects by dehydration, water loading and administration of mannitol. The ¹³¹I-Hippuran studies were performed in each condition. The time to peak and the half-time of the initial portion of the descending renal curve (T_1/2) were related to the urine flow rates. Above about 2 ml/min urine flow rate, changes in T_1/2 could largely be ascribed to changes in total renal clearance as determined from the half-time of a curve simultaneously obtained from the upper chest rather than to any effect of urine flow per se or of renal "washout." Urine flow rate should be determined in clinical renography to properly interpret retention of radioisotope by a kidney. Flow rates above 2 ml/min are recommended to avoid distortion of the renal area curves.

FOOTNOTES

^* Present address: Kansas City General Hospital and Medical Center, 24th and Cherry St., Kansas City, Mo.