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The Journal of Nuclear Medicine Vol. 11 No. 3 112-117
© 1970 by Society of Nuclear Medicine
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The Influence of Tissue Background Radioactivity on the Apparent Renal Accumulation of Radioactive Compounds

Melvin H. Farmelant*,, Charles E. Sachs{dagger} and Belton A. Burrows

University Hospital, Boston Veterans Administration Hospital and Boston University Medical Center, Boston, Massachusetts

Correspondence: For reprints contact: Melvin H. Farmelant, St. Vincent Hospital, 25 Winthrop St., Worcester, Mass. 01610.

ABSTRACT

The use of the upper chest as a measure of nonrenal tissue background in the renal areas was validated in dogs and patients. The role of tissue background in altering the curves of renal accumulation of radioisotopes was then explored.

The ratio of renal accumulation by the two kidneys would, from physiological considerations, be expected to remain constant for short times. Comparison of total counts in the renal areas reveal a varying ratio of uptake in people with significant discrepancies in initial counting rate. After tissue background is subtracted, the net kidney curves show a constant ratio of uptake in time in all cases. Evaluations of renal functions based on comparisons of uptake are dependent on significant differences in initial uptakes. It is suggested that methods of evaluation that reflect renal retention of radioisotope are more sensitive in detecting renal artery disease.

FOOTNOTES

* Present address: St. Vincent Hospital, Worcester, Mass.

{dagger} Present address: Hôpital Neckar, Paris, France.






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Copyright © 1970 by the Society of Nuclear Medicine.