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The Journal of Nuclear Medicine Vol. 11 No. 10 569-575
© 1970 by Society of Nuclear Medicine
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Simultaneous Study of the Absorption of Tritiated Pteroylglutamic Acid and 60Co-Vitamin B12

A. M. Musso, S. Kremenchuzky and E. M. Rochna Viola

Centro de Medicina Nuclear del Hospital Escuela José de San Martín, Buenos Aires, Argentina
Comisión Nacional de Energía Atómica, Argentina
St. Bartholomew's Hospital Medical College, London, England

Correspondence: For reprints contact: Arturo M. Musso. Rivadavia 7475, Buenos Aires, Argentina.

ABSTRACT

A method for the simultaneous study of the absorption of tritiated pteroylglutamic acid (3H-PGA) and 60Co-vitamin B12 is presented. The procedure consists of measuring the unabsorbed radioactivity by collecting and counting the feces after the administration of a single, combined oral dose of the labeled vitamins.

The accuracy of the method for simultaneously counting of 3H and 60Co in feces, by means of a liquid scintillation spectrometer, was assessed and proved to be satisfactory.

Simultaneous tests were performed in control subjects, patients with chronic atrophic gastritis and patients with megaloblastic anemia. The results of these tests are discussed.

The major advantage of this simultaneous method is that it gives a quantitative estimate of the absorption of two metabolically related compounds at the same point in time and under defined conditions. The method allows the study of the patient's response to specific therapeutic trials.

A computer program processes the results from this method in an accurate and rapid manner.






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Copyright © 1970 by the Society of Nuclear Medicine.