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Localization of ⁵⁸Co and ⁶⁵Zn-Hematoporphyrin Complexes in Canine Lymph Nodes

Donner Laboratory, University of California, Berkeley, California

Correspondence: For reprints contact: R. A. Fawwaz, Donner Laboratory and Donner Pavilion, University of California, Berkeley, Calif. 94720.

ABSTRACT

After the intravenous administration of ⁵⁸Co-hematoporphyrin to a series of dogs, the lymph nodes, kidneys and liver showed the highest uptake of radioactivity. Radiosensitive tissues such as the duodenal mucosa and the bone marrow showed much less concentration of radioactivity. These findings, coupled with the marked vulnerability of the lymph cells to irradiation, raises the possibility of selective lymph node irradiation using appropriate radioisotopic metallo-hematoporphyrins.