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Baboon Kidney Excretion of ²⁰³Hg-Chlormerodrin during Isolated Bloodless Perfusion

Walter Reed General Hospital, Washington, D.C.

P. D. R. van Heerden

University of Stellenbosch and Karl Bremer Hospital, Cape Province, South Africa

G. P. Murphy

Roswell Park Memorial Institute and State University of New York at Buffalo, Buffalo, New York

Correspondence: For reprints contact: Gerald S. Johnston, Chief, Radioisotope Clinic, Walter Reed General Hospital, Washington, D.C. 20012.

ABSTRACT

Over 30 baboon kidneys were studied during isolated bloodless perfusion with oxygen or helium equilibration and in the presence or absence of ureteral occlusion, low perfusion rates or protein addition to the system.

Renal cortical, medullary, venous, arterial and urinary ²⁰³Hg-chlormerodrin radioactivity was monitored during these experiments. Kidneys exposed to helium excrete and concentrate ²⁰³Hg-chlormerodrin in the same manner as oxygen-exposed kidneys or as intact kidneys in other species. These results suggest that ²⁰³Hg-chlormerodrin concentration and excretion under these isolated, bloodless conditions are not oxygen dependent.