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Intra-Arterial ¹⁸¹I-Macroaggregated Albumin to Define Intrahepatic Tumors: A Possible Method of Quantitating Tumor Response to Therapy

University of Wisconsin Medical Center, Madison, Wisconsin

Correspondence: For reprints contact: Ian B. Tyson, Radioisotope Service, Dept. of Radiology, University of Wisconsin Medical Center, 1300 University Ave., Madison, Wis. 53706.

ABSTRACT

Twelve patients being infused with chemotherapeutic agents through hepatic arterial catheters were injected with ¹³¹I macroaggregated albumin. Scans using this method are presented and suggest that positive images of hepatic abnormalities are produced. The method may be useful for more accurate evaluation of chemotherapy in patients being infused for hepatic metastatic disease. Further evaluation of these preliminary findings is currently under study both in patients and in animals.