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Localization of ^113mIn-Chelates Compared with ^99mTc-Sodium Pertechnetate in Experimental Cerebral Lesions

Baylor University College of Medicine, Houston, Texas

Correspondence: For reprints contact John A. Burdine, Jr., Nuclear Medicine Div., Dept. of Radiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas 77025.

ABSTRACT

A series of ^113mIn-tagged chelates was compared with ^99mTc-sodium pertechnetate for degree of localization in experimental brain lesions of dogs and hamsters. The lesion-to-brain ratios obtained when the two radionuclides were given simultaneously were consistently higher for indium-EDTA and DTPA. Because the rapid disappearance of these compounds from the blood reduces background contribution to total activity, they may prove to be the agents of choice for brain imaging.