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Comparison of Radioisotopic and Column Chromatographic Assay of Serum Thyroxine

Shigekoto Kaihara^*, Nicola Carulli and Henry N. Wagner, Jr.

The Johns Hopkins Medical Institutions, Baltimore, Maryland

Correspondence: For reprints contact: H. N. Wagner, Jr., The Johns Hopkins Medical Institutions, Dept. of Radiological Science, 615 N. Wolfe St., Baltimore, Md. 21205.

ABSTRACT

Serum thyroxine was determined in 108 sera by both the column and the radioisotopic method based on competitive binding of labeled thyroxine to thyroxine-binding globulin. Radioisotopic assay showed slightly higher values than the column method did. Correlation of the two methods was satisfactory (correlation coefficient = 0.967) except for nine cases in which exogenous iodine was believed to be present. In these nine cases, the results of thyroxine assay by the radioisotopic method agreed with the clinical diagnosis. The normal range for the radioisotopic thyroxine assay was 5.6–12.6 µg of thyroxine/100 ml. Five cases showed some overlapping between the normal and abnormal range, but all other cases showed good agreement with the clinical diagnosis.

FOOTNOTES

^* Present address: The second department of Internal Medicine, University of Tokyo, Tokyo, Japan.

Present address: Institute Clinica Medica Generale e Terapia Medica, Università di Modena, Modena, Italy.