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Total-Body Nitrogen and Protein Determined by In vivo Fast-Neutron Activation Analysis

National Institute of Radiological Sciences, Chiba, Japan

Isao Fujii, Haruo Muto and Tamon Inouye

Toshiba Central Research Laboratory, Kawasaki, Japan

Correspondence: For reprints contact: T. Nagai, Section of Nuclear Medicine, Dept. of Research and Isotopes, International Atomic Energy Agency, Kaerntner Ring 11, Vienna, Austria.

ABSTRACT

In vivo 14-MeV fast-neutron activation analysis for total-body nitrogen and protein in mice has been successfully performed with a high degree of accuracy. The results obtained with this technique agree to a high confidence level with the analyses performed by standard chemical methods. An appraisal of this study indicates that in vivo 14-MeV fast-neutron activation analysis is a simple, useful and nondestructive technique for measuring nitrogen and protein in the living body without serious radiation effects. Automated data processing with a digital computer gave highly accurate results.