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Distribution and Scintiphotography of a New Lung-Scanning Agent, ^99mTc-Macroaggregated Thionin: Studies in the Rodent

Stanford University School of Medicine, Palo Alto, California

Correspondence: For reprints contact: Joseph P. Kriss, Stanford Univ. School of Medicine, Dept. of Radiology, Stanford Medical Center, Palo Alto, Calif. 94304.

ABSTRACT

A method for synthesizing ^99mTc-macroaggregated thionin has been described. Distribution and scintiphotography studies in the rat and rabbit indicate that intravenously injected ^99mTc-MAT has an initial pulmonary uptake of 90% with subsequent gradual clearance from the lungs and transposition mainly to the liver, spleen and bone marrow. Hazard from radiation is considered to be low. Neither chemical toxicity nor hypersensitivity was observed in the rat and rabbit in the experiments designed. The amount which may be injected safely in humans has been discussed. The results suggest a potential usefulness of the aggregate in clinical lung scintillography. In view of its simple preparation and the physical characteristics of ^99mTc, it should be a useful addition to the present lung-scanning agents.