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Distribution and Scintiphotography Studies of ^99mTc-Iron Colloid in the Rabbit

Stanford University School of Medicine, Palo Alto, California

Correspondence: For reprints contact: Joseph P. Kriss, Dept. of Radiology, Stanford Medical Center, Palo Alto, Calif. 94304.

ABSTRACT

A method for synthesizing ^99mTc-Fe colloid has been described. The preparation consists of relatively small particles. Distribution and scintiphotography studies in rabbits indicate that about 40% of the intravenously injected colloid is rapidly excreted in the urine. The remainder is deposited chiefly in the bone marrow, kidneys and liver. Because of the relatively low uptake in the liver, the results suggest that the colloid is potentially useful in clinical scintigraphy of bone marrow. Hazards from iron toxicity or radiation are considered to be negligible.