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Sequential Determinations of the In Situ Distribution of ¹³¹I-Labeled Tetracycline in Cats Using the Scintillation Camera

U.S. Department of Health, Education and Welfare, Public Health Service, Bureau of Disease Prevention and Environmental Control, National Center for Radiological Health, Cincinnati, Ohio

Correspondence: For reprints contact: R. G. Wolfangel, Radionuclide Toxicology Laboratory, National Center for Radiological Health, 1090 Tusculum Ave., Cincinnati, Ohio 45226.

ABSTRACT

The use of the scintillation camera to rapidly obtain serial scintigraphs depicting the localization, relative concentration and gross turnover of radioactive materials in a living biological system is invaluable for studying potential radiopharmaceuticals. Scintigraphs of normal cats injected with ¹³¹I-labeled tetracycline are presented to illustrate the distribution and turnover pattern of this drug. Presently, we are in the process of evaluating ¹³¹I-labeled tetracycline as a radioscanning agent for the diagnosis of malignancies in animals using the technique described above.