HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Farmelant, M. H. Articles by Burrows, B. A. Search for Related Content PubMed PubMed Citation Articles by Farmelant, M. H. Articles by Burrows, B. A.

Physiological Determinants of Renal Tubular Passage Times

University Hospital, Boston University Medical Center and Boston Veterans Administration Hospital, Boston, Massachusetts

Correspondence: For reprints contact: Melvin H. Farmelant, Saint Vincent Hospital, 25 Winthrop St., Worcester, Mass. 01604.

ABSTRACT

The modal passage time and the spread of passage times through the renal tubules were determined in dogs following the intrarenal arterial injection of ¹³¹I-hippuran. These parameters were related to GFR, osmotic excretion and urine flow rates. An inverse relationship between GFR and passage time was present under all circumstances. In intact animals, passage time was relatively independent of osmotic excretion but in animals with suprarenal aortic constriction, passage time was significantly inversely correlated with osmotic excretion. These data suggest that in intact animals, tubular diameter increases with increasing bulk flow produced by osmotic loads to maintain fairly constant linear velocity. In the "underfilled" state accompanying aortic constriction, increasing bulk flow shortens passage time. The data clarify previous renographic observations that in renal arterial stenosis, mannitol loads preferentially reduce retention of radioisotope in the affected kidney.

FOOTNOTES

^* Present address: Charles University, Prague, Czechoslovakia.