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Cerebrovascular Permeability Studies in Cerebral Neoplasms and Vascular Lesions: Optimal Dose-to-Scan Interval for Pertechnetate Brain Scanning

Mayo Clinic and Mayo Foundation, Rochester, Minnesota

Correspondence: For reprints contact: W. N. Tauxe, Section of Clinical Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minn. 55901.

ABSTRACT

Brain scans were performed in a series of patients at various intervals after injection of ^98mTc-pertechnetate. The optimal interval between injection and scanning seems to be at least 3 hr. Our data suggest that scanning at this time leads to the greatest accuracy in diagnosing the positive scans with the least number of false-positive and false-negative reports. A method of analyzing scintiscan data is presented. This is based on the derivation of ratios based on actual counting rates obtained from digitized computer-processed scintiscan matrices.