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National Institute of Radiological Sciences, Chiba, Japan
Correspondence: For reprints contact: T. Nagai, Section of Nuclear Medicine, International Atomic Energy Agency, Kaerntner Ring 11, Vienna, Austria.
ABSTRACT
Body-potassium concentration and long-term rubidium whole-body retention have been measured by whole-body counting in patients with Duchenne muscular dystrophy and in genetic carriers.
In the patients and in some of the carriers, body-potassium concentration was significantly lower than that observed in normal subjects of similar ages. A shorter biological half-life of rubidium was also found. These results suggest that determination of body-potassium concentration and rubidium half-life using whole-body counting may assume a role in diagnosing progressive muscular dystrophy and might be valuable as an indicator of the genetic carrier state, possibly predicting the inheritance of the disease.
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