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The Journal of Nuclear Medicine Vol. 10 No. 1 1-7
© 1969 by Society of Nuclear Medicine
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Body-Potassium Concentration and Rubidium Metabolism Determined by Whole-Body Counting in Duchenne Muscular Dystrophy and Its Genetic Carrier State

Teruo Nagai, Hideo Sugita, Takeshi A. Iinuma, Tetsuo Furukawa and Shigeo Yashiro

National Institute of Radiological Sciences, Chiba, Japan

Correspondence: For reprints contact: T. Nagai, Section of Nuclear Medicine, International Atomic Energy Agency, Kaerntner Ring 11, Vienna, Austria.

ABSTRACT

Body-potassium concentration and long-term rubidium whole-body retention have been measured by whole-body counting in patients with Duchenne muscular dystrophy and in genetic carriers.

In the patients and in some of the carriers, body-potassium concentration was significantly lower than that observed in normal subjects of similar ages. A shorter biological half-life of rubidium was also found. These results suggest that determination of body-potassium concentration and rubidium half-life using whole-body counting may assume a role in diagnosing progressive muscular dystrophy and might be valuable as an indicator of the genetic carrier state, possibly predicting the inheritance of the disease.




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