FIGURE 2.  (A) Nominal percentage of ^99mTc-MDP in soft tissue plotted against AUC. K_total is estimated by extrapolating straight line fitted to 1-, 2-, 3-, and 4-h points to find terminal value of AUC₁. Note that 15-min point lies below straight line because equilibration between tracer in blood and tracer in soft tissue is not reached at this early time. (B) -Camera measurements of whole-body retention (WBR) plotted against AUC. Renal clearance of free ^99mTc-MDP was determined by extrapolating straight-line fit to find AUC₂. (C) Measurement of ^99mTc-MDP K_bone using Patlak plot. K_bone is determined from slope of straight line fitted to 2-, 3-, and 4-h time points.