FIGURE 3. Effect of spatial gaussian smoothing on regional DVt estimates given by voxelwise graphical analysis. 2TCM = VOI-based 2TCM with blood-volume correction; BVC = blood-volume correction; ctx. = cortex; GA = graphical analysis; PI GA and PI smoothed GA = parametric images generated by voxelwise graphical analysis without spatial gaussian smoothing and with spatial gaussian smoothing (filter kernel of 5 mm FWHM), respectively.