FIGURE 3.  IHC of tumor biopsies from 2 representative patients. (Top row) Moderately differentiated squamous cell carcinoma (patient 12) with high ¹⁸F-FDG uptake and minimal ¹⁸F-FMISO uptake on PET studies. (Bottom row) Moderately differentiated adenocarcinoma (patient 15) in which expression of all tumor markers was similar despite higher ¹⁸F-FMISO uptake on PET studies. (GLUT1, HIF-1, VEGF, and Ki67, x400; VWF, x200)