FIGURE 4.  Box plot showing inverse relationship between plasma concentration of sum of all LNAAs (A) and Kcplx macroparameter (B). Box itself contains middle 50% of data, with line in box indicating median value. Ends of vertical lines, representing maximum and minimum data values, and points outside this range are considered outliers. The significantly lower total LNAA levels found in women (P = 0.012) appear related to significantly higher estimates of Kcplx macroparameter in women than in men (P = 0.011). (C) Kcplx macroparameter value for men and women after normalization to standard total plasma LNAA concentration of 1,000 µmol/L.