FIGURE 1. Severe rest perfusion defect. (A) Topographic display. Top panel shows topographic display of unshifted images with artifactual defect due to misregistration of emission and attenuation data. Middle panel shows topographic display of same patient after shifting emission images for optimal coregistration with attenuation image. Bottom panel shows our myocardial perfusion map relating 3D quadrant views of PET images to arterographic anatomy from (4). RI = ramus intermedius; OM₁ = first obtuse marginal branch; OM₂ = second obtuse marginal branch; LCx = left circumflex artery; D₁ = first diagonal branch; D₂ = second diagonal branch; RCA = right coronary artery; LAD = left anterior descending (artery). (B) Quantitative analysis of misregistration. Top panel shows rotated transmission images in scanner horizontal longitudinal section before shifting (left) and after shifting emission data (right) with superimposed outline of emission image in same tomographic slice using same rotation angles. Middle panel shows rotated transmission images in scanner vertical longitudinal section before shifting (left) and after shifting emission data (right) with superimposed outline of emission image in same tomographic slice using same rotation angles. Bottom panel shows transmission images (red color) in in-plane acquisition tomographic view using shift software with emission image superimposed (yellow color) before (left) and after shifting emission images (right) showing misregistration area (green) between emission and transmission images.