FIGURE 3. (A) Functional interactions between the EC and the rest of the brain in AD patients. (Top) Results (black blobs) are displayed as SPM projections in the 3 orthogonal right sagittal, posterior coronal, and superior axial views (P < 0.001, uncorrected for multiple comparisons). Local maxima of regions of correlated activity can be found in Tables 5 and 6. (Bottom) Areas showing significant correlations are displayed on the axial slices of a standard MR image beginning at -26 mm relative to the AC–PC line (upper left of image) and extending up to 44 mm above the AC–PC line (lower right of image). Images are displayed in neurologic convention (left is left and right is right). t-Value color-coded scale is shown at the bottom right. (B) ¹⁸F-FDG PET images of a 77-y-old woman with AD. Eight coronal slices orthogonal to the long temporal axis (top row) and axial slices parallel to the frontooccipital plane (bottom row) are shown. In this case, a coupled metabolic reduction in the temporoparietal cortex and in the ipsilateral medial temporal cortex (arrows) is evident.