FIGURE 11. Hepatic metastasis in 47-y-old female patient with cancer of unknown primary. (A) Contrast-enhanced CT could not clearly distinguish between viable tumor tissue and normal liver parenchyma. (B) PET imaging demonstrated increased glucose metabolism. (C) Increased tracer uptake was accurately localized based on PET/CT images. (D) Additional manual fusion of PET/CT images with interventional images showed biopsy device to be within viable tumor tissue.