FIGURE 2. A 50-y-old man with recurrent HNSCC in a cervical lymph node underwent PET/CT imaging before and after completion of chemotherapy. (A) Pretherapy axial CT (left) and PET (right) images reveal intense radiotracer uptake in a right jugular lymph node (arrow on PET image) in the same anatomic location as lymphadenopathy seen on corresponding CT image. (B) Posttherapy axial CT (left) and PET (right) images reveal persistent ¹⁸F-FDG uptake in the corresponding locations (arrow), consistent with residual disease and therapy failure. Patient’s disease subsequently further progressed. PET/CT studies were obtained on a GE Discovery LS unit—a PET/CT fusion system combining GE LightSpeed multislice CT and Advance NXi PET (GE Medical Systems).