FIGURE 3. Effect of quantity of peptide on tissue distribution. Melanoma-bearing mice were injected with 185 kBq 67Ga-DOTA-NAPamide (9.25 GBq/µmol) supplemented with various amounts of nonradioactive Ga-DOTA-NAPamide to obtain total peptide quantity per mouse of 20 pmol (
), 170 pmol (
), or 420 pmol (
). Radioactivity accumulated in main tissues was measured 4 h after injection and results are expressed as percentage of uptake (%ID/g) observed after injection of 20 pmol (mean ± SEM, n = 3 or 4). *P < 0.05,
P < 0.001 vs. 20 pmol. SI = small intestine.