FIGURE 1. Typical images show histology and corresponding radioluminographs show radionuclide distribution within tumor sections. H&E demonstrates general morphology (top), staining viable regions (V) darker than necrotic regions (N). Hypoxia was demonstrated using immunohistochemical method to detect 2-nitroimidazole metabolites (bottom). Bar = 2.0 mm. High-resolution image shows detail from ¹⁸F-FDG image.