FIGURE 2. Adjacent serial sections indicate that immunostaining with antisera to AßPP shows localization of amyloid plaques (A) and that intranasally injected SAP binds to amyloid plaques in Tg mouse cortex as detected by antibody to SAP (B). (D) Brain sections from Tg mice receiving bovine serum albumin plus vehicle immunostained for SAP show no reaction in amyloid plaques, although many plaques are seen on adjacent serial sections stained for AßPP (C). Scale bar = 50 µm. Arrows mark same plaques in serial sections (A and B) and (C and D).