FIGURE 3. Liver time–activity data with model simulations from two representative studies: sham-operated rat and shunted rat. _o of sham-operated rat was 0.286 ± 0.007 nmol/g; receptor concentration [R]_o was 0.901 ± 0.021 µmol/L. Shunted rat had _o of 0.018 ± 0.001 nmol/g and [R]_o of 0.273 ± 0.001 mol/L. kcts = kilocounts.